Improving Cell Membrane Health in Children with Cystic Fibrosis Using 5-MTHF and Vitamin B12
Author Information
Author(s): Scambi Cinzia, De Franceschi Lucia, Guarini Patrizia, Poli Fabio, Siciliano Angela, Pattini Patrizia, Biondani Andrea, La Verde Valentina, Bortolami Oscar, Turrini Francesco, Carta Franco, D'Orazio Ciro, Assael Baroukh M., Faccini Giovanni, Bambara Lisa M.
Primary Institution: University of Verona, Verona, Italy
Hypothesis
Can 5-methyltetrahydrofolate (5-MTHF) and vitamin B12 supplementation improve red blood cell membrane features in children with cystic fibrosis?
Conclusion
5-MTHF and vitamin B12 supplementation may enhance red blood cell membrane characteristics in children with cystic fibrosis.
Supporting Evidence
- Supplementation increased plasma and red cell folate levels.
- Plasma homocysteine levels decreased after supplementation.
- Red blood cell membrane oxidative damage was reduced.
- Red blood cell potassium content increased.
- Fatty acid composition of red blood cell membranes was modified.
Takeaway
This study found that giving certain vitamins to kids with cystic fibrosis can help make their blood cells healthier.
Methodology
A single-arm trial was conducted with 31 children with cystic fibrosis, who received 5-MTHF and vitamin B12 supplementation for 24 weeks.
Potential Biases
Potential bias due to lack of randomization and control group.
Limitations
The study lacked a control group not receiving supplementation.
Participant Demographics
Children aged 3 to 8 years with cystic fibrosis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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