The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
2009
Understanding Neuronal Cell Death in Neurodegenerative Diseases
publication
Evidence: moderate
Author Information
Author(s): Todd E Golde
Primary Institution: Mayo Clinic
Hypothesis
Therapies targeting the triggers of neurodegenerative diseases may be more effective if given during the prodromal phase or earlier.
Conclusion
Preventing neuronal death and dysfunction could provide significant clinical benefits in neurodegenerative diseases.
Supporting Evidence
- Most neurodegenerative diseases have a long asymptomatic phase before symptoms appear.
- Therapies targeting disease triggers may be ineffective if given after significant neuronal damage has occurred.
- Understanding the pathways leading to neuronal death is crucial for developing effective therapies.
Takeaway
This study talks about how understanding what causes brain cells to die can help us find better treatments for diseases like Alzheimer's and Parkinson's.
Limitations
The study highlights the lack of understanding of neuronal death pathways in neurodegenerative disorders.
Digital Object Identifier (DOI)
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