Statin-Induced Myopathy in Zebrafish
Author Information
Author(s): Huang Shih-Hao, Hsiao Chung-Der, Lin Dar-Shong, Chow Cho-Yen, Chang Chia-Jen, Liau Ian
Primary Institution: National Chiao Tung University
Hypothesis
The study investigates the myopathy caused by statin in zebrafish using second-harmonic generation imaging.
Conclusion
Statin treatment caused significantly shortened sarcomeres in zebrafish, indicating potential for early diagnosis of myopathy.
Supporting Evidence
- Statin treatment caused a significant shortening of the sarcomere relative to an untreated control.
- The ability to determine microstructural modification of sarcomeres allows diagnosis of muscle injury before conventional clinical symptoms.
- The microstructural disorder exhibited a strong dependence on both the dosage and the duration of treatment.
Takeaway
The study shows that statins can make muscles shorter in zebrafish, which helps scientists understand muscle problems better.
Methodology
Second-harmonic generation imaging was used to assess the myotoxicity of statins in zebrafish.
Limitations
The study primarily focuses on zebrafish, which may not fully represent human muscle responses.
Participant Demographics
Zebrafish larvae at various developmental stages.
Statistical Information
P-Value
1.73±0.09 µm vs 1.91±0.08 µm, P<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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