Identification of a Conserved Anti-Apoptotic Protein That Modulates the Mitochondrial Apoptosis Pathway
2011
CAAP Regulates Caspase-10 in Apoptosis
publication
Evidence: high
Author Information
Author(s): Zhang Yu, Johansson Elisabet, Miller Marian L., Jänicke Reiner U., Ferguson Donald J., Plas David, Meller Jarek, Anderson Marshall W.
Primary Institution: University of Cincinnati
Hypothesis
CAAP functions as an anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial apoptosis pathway.
Conclusion
The study suggests that CAAP is a target for chemotherapeutic agents as it regulates apoptosis through caspase-10.
Supporting Evidence
- CAAP is expressed in all human tissues examined.
- Knockdown of CAAP induced apoptosis in A-549 and MCF-7/casp3-10b cells.
- Apoptosis was associated with increased caspase-10 expression and activation.
- Both caspase-3 and -10 are required for apoptosis induced by CAAP knockdown.
Takeaway
CAAP is a protein that helps keep cells alive, and when it's removed, cells start to die. This could help doctors find new ways to treat cancer.
Methodology
The study involved RNAi knockdown of CAAP in cancer cell lines to assess apoptosis and caspase activation.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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