Study on TNF-alpha Gene Polymorphisms and Psoriatic Arthritis in Romanians
Author Information
Author(s): Popa Olivia M., Bojinca Mihai, Bojinca Violeta, Dutescu Monica I., Meirosu Mihaela, Caisan Ruxandra E., Ciofu Claudia, Bara Constantin, Popa Luis O.
Primary Institution: University Carol Davila, Bucharest, Romania
Hypothesis
The study investigates the association of three TNF-alpha gene polymorphisms with psoriatic arthritis in a Romanian population.
Conclusion
The TNF-alpha −857C/T polymorphism is associated with susceptibility to psoriatic arthritis in the Romanian population.
Supporting Evidence
- The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis at the individual level.
- No association was found with undifferentiated spondyloarthritis.
- The study included a control group of healthy Romanian individuals.
Takeaway
This study found that a specific gene variation is linked to a higher chance of developing psoriatic arthritis in people from Romania.
Methodology
A case-control association study comparing TNF-alpha gene polymorphisms in psoriatic arthritis patients and ethnically matched controls.
Limitations
The findings require further validation on a larger group of patients.
Participant Demographics
86 Romanian patients with psoriatic arthritis (42 males, 44 females, mean age 51 years) and 79 with undifferentiated spondyloarthritis (30 males, 49 females, mean age 37.5 years).
Statistical Information
P-Value
0.03
Confidence Interval
95% CI 1.05–2.57
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website