New Centromeres in Primates
Author Information
Author(s): Mariana Lomiento, Zhaoshi Jiang, Pietro D'Addabbo, Evan E Eichler, Mariano Rocchi
Primary Institution: Department of Genetics and Microbiology, University of Bari
Hypothesis
The absence of genes in the seeding area constitutes a crucial condition for the evolutionary-new centromere fixation in the population.
Conclusion
The study suggests that the absence of genes is a favorable condition for the fixation of evolutionary-new centromeres in primates.
Supporting Evidence
- The absence of genes in the seeding regions was found to be statistically significant.
- Restructuring of the seeding regions is an intrinsic property of novel evolutionary centromeres.
- The study identified 14 evolutionary-new centromeres in primates.
Takeaway
The study found that new centromeres in primates tend to form in areas without genes, which helps them become stable.
Methodology
The study characterized 14 evolutionary-new centromeres and assessed genomic restructuring and gene density in the ancestral domains.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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