Effects of Raloxifene and Alendronate on Vertebral Bone
Author Information
Author(s): Diab Tamim, Wang Jason, Reinwald Susan, Guldberg Robert E, Burr David B
Primary Institution: Indiana University School of Medicine
Hypothesis
The combination of RAL and ALN will improve bone's structural properties more than each agent alone.
Conclusion
The combination treatment of raloxifene and alendronate has beneficial effects on bone volume, resulting in improvement in the structural properties of vertebral bone.
Supporting Evidence
- The OVX + RAL + ALN group had a 6.3% higher aBMD than the OVX + RAL group.
- The structural biomechanical properties of vertebral bone are improved with the combination treatment.
- Turnover rates of both the RAL + ALN and ALN alone groups were lower than in the RAL-treated alone group.
Takeaway
Giving two medicines together can make bones stronger than using just one medicine by itself.
Methodology
Eighty-six-month-old Sprague-Dawley rats were randomized into five experimental groups and treated with RAL, ALN, or both, followed by biomechanical testing and histomorphometric measurements.
Limitations
The derived material properties are estimates and the histomorphometric analysis was done on tibia, not vertebra.
Participant Demographics
Sprague-Dawley rats, six months old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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