Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway
2011
Rab5a and Its Role in Cervical Cancer Cell Movement
Sample size: 31
publication
Evidence: moderate
Author Information
Author(s): Liu Shan-shan, Chen Xiang-mei, Zheng Hong-xia, Shi Shu-liang, Li Yu
Primary Institution: Harbin Institute of Technology
Hypothesis
Rab5a influences cervical cancer cell invasion and metastasis through integrin-mediated signaling pathways.
Conclusion
Rab5a regulates cancer cell motility and invasion by affecting integrin-mediated signaling pathways.
Supporting Evidence
- Rab5a was expressed at a high level in cervical cancer tissues.
- Silencing Rab5a significantly decreased cancer cell motility and invasiveness.
- Down-regulation of integrin-associated signaling molecules was observed in Rab5a knockdown cells.
Takeaway
Rab5a is a protein that helps cancer cells move and spread. When we reduce its levels, the cancer cells can't move as well.
Methodology
The study used immunohistochemical analysis, RNA interference to knock down Rab5a, and assessed cell motility through invasion and wound migration assays.
Participant Demographics
Cervical cancer tissues from 31 patients were analyzed.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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