Analysis of Human Gene Expression in Different Tissues
Author Information
Author(s): Dezső Zoltán, Nikolsky Yuri, Sviridov Evgeny, Shi Weiwei, Serebriyskaya Tatiana, Dosymbekov Damir, Bugrim Andrej, Rakhmatulin Eugene, Brennan Richard J, Guryanov Alexey, Li Kelly, Blake Julie, Samaha Raymond R, Nikolskaya Tatiana
Primary Institution: GeneGo, Inc.
Hypothesis
The study aims to identify tissue-specific and housekeeping genes through comprehensive functional analysis.
Conclusion
The analysis revealed that housekeeping and tissue-specific genes have distinct biological functions consistent with their tissue origins.
Supporting Evidence
- The study identified 2374 housekeeping genes expressed in all tissues.
- Tissue-specific genes were found to be twice as likely to be drug targets compared to housekeeping genes.
- The network analysis showed distinct properties for tissue-specific networks.
Takeaway
Scientists looked at how genes work in different parts of the body and found that some genes are important for all tissues, while others are special for certain tissues.
Methodology
The study involved analyzing gene expression across 31 human tissues using a whole-genome microarray.
Statistical Information
P-Value
p<10–77
Statistical Significance
p<10–77
Digital Object Identifier (DOI)
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