Genome-Wide Association of Bipolar Disorder Suggests an Enrichment of Replicable Associations in Regions near Genes
Author Information
Author(s): Erin N. Smith, Daniel L. Koller, Corrie Panganiban, Szabolcs Szelinger, Peng Zhang, Judith A. Badner, Thomas B. Barrett, Wade H. Berrettini, Cinnamon S. Bloss, William Byerley, William Coryell, Howard J. Edenberg, Tatiana Foroud, Elliot S. Gershon, Tiffany A. Greenwood, Yiran Guo, Maria Hipolito, Brendan J. Keating, William B. Lawson, Chunyu Liu, Pamela B. Mahon, Melvin G. McInnis, Francis J. McMahon, Rebecca McKinney, Sarah S. Murray, Caroline M. Nievergelt, John I. Nurnberger Jr., Evaristus A. Nwulia, James B. Potash, John Rice, Thomas G. Schulze, William A. Scheftner, Paul D. Shilling, Peter P. Zandi, Sebastian Zöllner, David W. Craig, Nicholas J. Schork, John R. Kelsoe
Primary Institution: Scripps Genomic Medicine and Scripps Translational Science Institute
Hypothesis
Is there an underlying genetic signal for bipolar disorder that can be detected through power analysis across multiple studies?
Conclusion
The study suggests that common genetic variation associated with bipolar disorder is likely found near exons, which could be identified in larger studies.
Supporting Evidence
- The study genotyped 1,190 BD cases and 401 controls to find genetic regions associated with BD.
- An association was found between the power to detect effects and evidence for replication.
- SNPs near exons showed a greater probability of replication, indicating an enrichment of associations near functional regions of genes.
- Results suggest that common genetic variation associated with BD is likely found near exons.
Takeaway
Scientists looked at the genes of people with bipolar disorder to find patterns. They think that many small changes in genes near important parts of DNA might be linked to the disorder.
Methodology
The study performed a genome-wide association study (GWAS) using genotype data from 2,191 cases and 1,434 controls, analyzing SNPs for associations with bipolar disorder.
Limitations
The study did not find genome-wide significant associations for individual loci, indicating potential limitations in power and sample size.
Participant Demographics
The study included 2,191 cases of bipolar disorder and 1,434 controls, primarily of European ancestry.
Statistical Information
P-Value
1.5×10−7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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