Alcohol Related Changes in Regulation of NMDA Receptor Functions
2008
Alcohol and NMDA Receptor Function
publication
Evidence: moderate
Author Information
Author(s): Nagy József
Primary Institution: Gedeon Richter Plc.
Hypothesis
Long-term alcohol exposure alters NMDA receptor functions, contributing to alcohol dependence.
Conclusion
Chronic alcohol consumption leads to changes in NMDA receptor expression and function, which may contribute to alcohol tolerance and dependence.
Supporting Evidence
- Chronic alcohol exposure increases NMDA receptor function and expression.
- Alcohol withdrawal is associated with increased NMDA receptor activity.
- Changes in NMDA receptor subunit expression are linked to alcohol dependence.
Takeaway
Drinking a lot of alcohol can change how certain brain receptors work, making it harder to stop drinking later.
Methodology
This review summarizes various studies on the effects of chronic alcohol exposure on NMDA receptor functions and their implications.
Limitations
The review discusses findings from various studies, which may have differing methodologies and results.
Digital Object Identifier (DOI)
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