Inflamm-aging is Not Universal Across Human Populations
Author Information
Author(s): Franck Maximilien, Tanner Kamaryn, Ferrucci Luigi, Gurven Michael, Mehrjerd Ameneh, Yeong Joe, Hertel Johannes, Cohen Alan A
Hypothesis
Is inflamm-aging a universal aging mechanism across diverse human populations?
Conclusion
Inflamm-aging is not a universal phenomenon, as significant differences in immune variation and its relation to chronic diseases were observed across different populations.
Supporting Evidence
- Inflamm-aging was observed to vary significantly across different populations.
- The primary immune axis in the Tsimane cohort diverged from those in industrialized cohorts.
- Chronic disease associations with inflammation differed across the studied populations.
Takeaway
The way our bodies age and respond to inflammation can be very different depending on where we live and our lifestyle, not the same for everyone.
Methodology
We used principal components and factor analysis to study immune variation across four different populations.
Limitations
The study may not cover all human populations and focuses on specific cohorts.
Participant Demographics
The study included diverse populations such as industrialized cohorts and non-industrialized Amerindian forager-horticulturalists.
Digital Object Identifier (DOI)
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