Rab23 is a flagellar protein in Trypanosoma brucei
2011
Rab23 is a flagellar protein in Trypanosoma brucei
publication
Evidence: moderate
Author Information
Author(s): Lumb Jennifer H, Field Mark C
Primary Institution: Cambridge Institute for Medical Research
Hypothesis
Is Rab23 an example of a Rab protein with divergent function in distinct taxa?
Conclusion
Rab23 is located at the flagellum in Trypanosoma brucei, suggesting a conserved role in flagellar function.
Supporting Evidence
- Rab23 is conserved in its location at the flagellum across different species.
- Rab23 is not essential for the construction or maintenance of the flagellum in Trypanosoma brucei.
- Rab23 is associated with basal bodies and flagellar structures.
Takeaway
Rab23 is a protein found in the flagellum of a tiny organism called Trypanosoma brucei, and it helps with how the flagellum works.
Methodology
The study involved examining the taxonomic distribution of Rab23, localizing it using epitope-tagging, and performing RNAi knockdown experiments.
Limitations
The study did not find a flagellar defect upon RNAi knockdown of Rab23, suggesting potential redundancy with other proteins.
Digital Object Identifier (DOI)
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