Skin Permeation of Antiseptics in Animals
Author Information
Author(s): Jessica Stahl, Michael Braun, Joerg Siebert, Manfred Kietzmann
Primary Institution: University of Veterinary Medicine Hannover, Foundation
Hypothesis
The study aims to investigate whether octenidine dihydrochloride or 2-phenoxyethanol permeate through animal skin in vitro.
Conclusion
Octenidine dihydrochloride is suitable for superficial skin treatment due to its low absorption rates, while 2-phenoxyethanol's high absorption rate poses potential toxicological risks.
Supporting Evidence
- No octenidine dihydrochloride was found in the receptor chamber of intact skin samples after 28 hours.
- 2-phenoxyethanol permeated through all skin samples with the highest permeability in equine skin.
- Both components were found in the stratum corneum and dermis of all split skin samples.
Takeaway
The study looked at how well two antiseptics can pass through animal skin. One didn't go through much at all, while the other went through a lot, which could be risky.
Methodology
Permeation studies were conducted using Franz-type diffusion cells with skin samples from cats, dogs, cows, and horses.
Limitations
The study only examined in vitro permeation and did not assess in vivo effects or long-term safety.
Participant Demographics
Skin samples were obtained from various animal species including cats, dogs, cows, and horses.
Digital Object Identifier (DOI)
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