Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
2011
Herpesvirus Interactions with Rho GTPase Signaling
publication
Evidence: moderate
Author Information
Author(s): Van den Broeke Céline, Favoreel Herman W.
Primary Institution: Ghent University
Hypothesis
How do herpesviruses interact with Rho GTPase signaling pathways during their replication cycle?
Conclusion
Herpesviruses significantly alter Rho GTPase signaling, which affects their entry, replication, and spread.
Supporting Evidence
- Herpesviruses can manipulate Rho GTPase signaling to facilitate their entry into host cells.
- Different herpesvirus subfamilies interact with Rho GTPase signaling in unique ways.
- Rho GTPase signaling is crucial for the efficient delivery of herpesvirus particles to the nucleus.
Takeaway
Herpesviruses use special tricks to interact with the cell's structure, helping them enter and spread inside the body.
Methodology
The review summarizes various studies on herpesvirus interactions with Rho GTPase signaling.
Limitations
The review does not cover all interactions between herpesviruses and the actin cytoskeleton.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website