Insecticide Resistance in Malaria Vectors in Sri Lanka
Author Information
Author(s): Devika B Perera, Janet Hemingway, SH Parakrama Karunaratne
Primary Institution: Regional Office, Anti Malaria Campaign, Kurunegala, Sri Lanka
Hypothesis
What are the mechanisms of insecticide resistance in Anopheles mosquitoes in Sri Lanka?
Conclusion
The study highlights the complexity of insecticide resistance mechanisms in malaria vectors, emphasizing the need for new molecular tools for effective control.
Supporting Evidence
- All Anopheles culicifacies and Anopheles subpictus populations showed high resistance to DDT.
- Resistance to malathion was observed in all populations except for An. culicifacies from Kurunegala.
- Different levels of resistance to pyrethroids were found among the populations.
- Elevated levels of esterases, GSTs, and monooxygenases were noted in resistant populations.
Takeaway
Mosquitoes that spread malaria in Sri Lanka are becoming resistant to insecticides, making it harder to control the disease.
Methodology
Adult female mosquitoes were exposed to various insecticides, and resistance mechanisms were assessed using biochemical techniques.
Limitations
The study may not cover all regions or species of Anopheles in Sri Lanka.
Participant Demographics
The study involved Anopheles culicifacies and Anopheles subpictus from five districts in Sri Lanka.
Digital Object Identifier (DOI)
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