Effects of Activin BetaA on Reproductive Function in Mice
Author Information
Author(s): Kim Mi-Nyeu, Park Moon Nyeo, Jung Hoi Kyung, Cho Chunghee, Mayo Kelly E, Cho Byung-Nam
Primary Institution: The Catholic University of Korea
Hypothesis
What are the effects of intramuscular injection of an activin betaA-expressing plasmid on reproductive function and embryo development in mice?
Conclusion
Activin betaA can directly influence the estrous cycle and embryo development in female mice.
Supporting Evidence
- Activin betaA mRNA was detected in the muscle after injection.
- Increased serum activin levels corresponded with elevated FSH levels.
- The estrous cycle was extended in the injected female mice.
- Increased numbers of corpora lutea were observed in the ovaries of injected mice.
- Some embryos died in utero, while surviving embryos were heavier than controls.
Takeaway
The study shows that a special protein called activin betaA can change how female mice reproduce and how their babies grow.
Methodology
Female adult mice were injected with an activin betaA-expressing plasmid, and various reproductive parameters were assessed.
Limitations
The study primarily focused on female mice, and the effects on male mice were not significantly observed.
Participant Demographics
ICR mice at 2 months of age.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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