Sang Froid in a time of trouble: is a vaccine against HIV possible?
2009
Is a Vaccine Against HIV Possible?
Commentary
Author Information
Author(s): Stanley A Plotkin
Primary Institution: University of Pennsylvania
Hypothesis
Can we develop an effective vaccine against HIV given the challenges faced in previous vaccine trials?
Conclusion
While the situation regarding an HIV vaccine is serious, it is not hopeless, and lessons from past vaccine developments can guide future efforts.
Supporting Evidence
- The STEP trial results were disappointing, indicating that the vaccine failed to control viral load.
- Previous vaccines have faced similar challenges, providing lessons for future HIV vaccine development.
- Immunity correlates can be complex, and both antibody and cellular responses are important.
Takeaway
This article discusses the challenges of creating an HIV vaccine and suggests that while it's tough, we can learn from past vaccine experiences to improve our chances.
Potential Biases
The author is a paid consultant to vaccine manufacturers, which may introduce bias.
Limitations
The author is not an expert in HIV or immunology, which may limit the depth of analysis.
Digital Object Identifier (DOI)
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