New Genetic Loci for Parkinson's Disease Identified
Author Information
Author(s): Vincent Plagnol, Michael A. Nalls, Jose M. Bras, Dena G. Hernandez, Manu Sharma, Una-Marie Sheerin, Javier Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Philippe Amouyel, Sampath Arepalli, Gavin Band, Roger A. Barker, Céline Bellinguez, Yoav Ben-Shlomo, Henk W. Berendse, Daniela Berg, Kailash Bhatia, Rob M. A. de Bie, Alessandro Biffi, Bas Bloem, Zoltan Bochdanovits, Michael Bonin, Kathrin Brockmann, Janet Brooks, David J. Burn, Gavin Charlesworth, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E. Clarke, Mark R. Cookson, J. Mark Cooper, Jean Christophe Corvol, Carl Counsell, Philippe Damier, Jean-François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D. van Dijk, Allissa Dillman, Frank Durif, Alexandra Dürr, Sarah Edkins, Jonathan R. Evans, Thomas Foltynie, Colin Freeman, Jianjun Gao, Michelle Gardner, J. Raphael Gibbs, Alison Goate, Emma Gray, Rita Guerreiro, Ómar Gústafsson, Clare Harris, Garrett Hellenthal, Jacobus J. van Hilten, Albert Hofman, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Heiko Huber, Gavin Hudson, Sarah E. Hunt, Johanna Huttenlocher, Thomas Illig, Pálmi V. Jónsson, Cordelia Langford, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Alisdair McNeill, Catriona Moorby, Matthew Moore, Huw Morris, Karen E. Morrison, Ese Mudanohwo, Sean S. O'Sullivan, Justin Pearson, Richard Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Matti Pirinen, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamas Revesz, Olaf Riess, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Ellen Sidransky, Rohan de Silva, Colin Smith, Chris C. A. Spencer, Hreinn Stefánsson, Stacy Steinberg, Joanna D. Stockton, Amy Strange, Zhan Su, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, François Tison, Daniah Trabzuni, Bryan J. Traynor, André G. Uitterlinden, Jana Vandrovcova, Daan Velseboer, Marie Vidailhet, Damjan Vukcevic, Robert Walker, Bart van de Warrenburg, Michael E. Weale, Mirdhu Wickremaratchi, Nigel Williams, Caroline H. Williams-Gray, Sophie Winder-Rhodes, Kári Stefánsson, Maria Martinez, Peter Donnelly, Andrew B. Singleton, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Nick W. Wood
Primary Institution: UCL Genetics Institute, University College London, London, United Kingdom
Hypothesis
Can genome-wide association studies identify new genetic loci associated with Parkinson's disease?
Conclusion
The study identified five new genetic loci associated with Parkinson's disease, enhancing understanding of its genetic basis.
Supporting Evidence
- The study combined data from over 12,000 Parkinson's disease cases and 21,000 controls.
- Five new loci were identified that passed genome-wide significance thresholds.
- Previous studies had identified 11 loci, and this study adds to that knowledge.
- Findings suggest potential molecular mechanisms for Parkinson's disease risk.
- Results were replicated in an independent dataset of over 3,000 cases.
Takeaway
Scientists found new places in our genes that might make people more likely to get Parkinson's disease, helping us understand the illness better.
Methodology
The study used a two-stage meta-analysis combining data from genome-wide association studies with over 12,000 cases and 21,000 controls.
Limitations
The study may not fully capture all genetic variants due to the complexity of Parkinson's disease.
Participant Demographics
Participants included over 12,000 cases of Parkinson's disease and 21,000 controls from various cohorts.
Statistical Information
P-Value
p<5×10−10
Confidence Interval
95% CI for odds ratios reported
Statistical Significance
p<5×10−10
Digital Object Identifier (DOI)
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