Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
2011
How X11-Like Protein Affects Amyloid Precursor Protein in Cells
publication
Evidence: moderate
Author Information
Author(s): Saito Yuhki, Akiyama Mayu, Araki Yoichi, Sumioka Akio, Shiono Maki, Taru Hidenori, Nakaya Tadashi, Yamamoto Tohru, Suzuki Toshiharu
Primary Institution: Hokkaido University, Sapporo, Japan
Hypothesis
X11-like protein regulates the intracellular trafficking of amyloid β-protein precursor (APP).
Conclusion
X11L helps to accumulate immature APP in the early secretory pathway, reducing the generation of amyloid β.
Supporting Evidence
- X11L suppresses amyloidogenic cleavage of mature APP.
- X11L accumulates immature APP in the early secretory pathway.
- Some accumulated immature APP appears on the plasma membrane.
- X11 family proteins regulate APP metabolism at multiple steps.
Takeaway
X11L is like a helper that keeps a protein called APP from turning into a bad substance that can cause Alzheimer's disease.
Methodology
The study involved functional dissection of X11L using various domain-deleted mutants to analyze APP trafficking and metabolism.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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