Protective Effects of Buyang Huanwu Decoction on Myocardial Injury
Author Information
Author(s): Yang Guangde, Fang Zhiyuan, Liu Yu, Zhang Hui, Shi Xiaolian, Ji Qiaoli, Lin Qinqin, Lin Rong
Primary Institution: Xi'an Jiaotong University, School of Medicine
Hypothesis
The protective effect of Buyang Huanwu Decoction (BYHWD) on myocardial ischemia was investigated.
Conclusion
BYHWD has a protective effect against myocardial ischemia induced by isoproterenol in rats.
Supporting Evidence
- Pre-treatment with BYHWD improved ECG changes associated with myocardial ischemia.
- BYHWD significantly decreased the activities of LDH, CK, and AST in serum compared to the model group.
- BYHWD reduced the levels of NO, NOS, and iNOS in serum.
- BYHWD decreased the expression of iNOS and CD40L in myocardial tissues.
Takeaway
This study shows that a traditional Chinese medicine called Buyang Huanwu Decoction can help protect the heart from damage caused by lack of blood flow.
Methodology
Rats were treated with different doses of BYHWD and isoproterenol was used to induce myocardial ischemia; various biochemical markers were measured.
Limitations
The study primarily used animal models, and the effects in humans are not yet established.
Participant Demographics
Sixty male adult Sprague-Dawley rats weighing 180–200 g.
Statistical Information
P-Value
p<0.05 or p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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