Visceral Fat and Kidney Function in HIV Patients
Author Information
Author(s): Grima Pierfrancesco, Zizza Antonella, Guido Marcello, Tundo Paolo, Chiavaroli Roberto
Primary Institution: Division of Infectious Diseases, HIV Center, “S.Caterina Novella” Hospital, Galatina, Italy
Hypothesis
Is perirenal fat thickness related to kidney function and intrarenal artery resistive index in HIV-1-infected patients?
Conclusion
Ultrasonographic assessment of perirenal fat thickness may serve as a marker of increased endothelial damage in HIV-1-infected patients.
Supporting Evidence
- Patients with visceral obesity had higher perirenal fat thickness and intrarenal artery resistive index.
- Age and perirenal fat thickness were independent factors associated with intrarenal artery resistive index.
- Ultrasound-measured perirenal fat thickness correlated with intrarenal artery resistive index.
Takeaway
This study found that having more fat around the kidneys can be linked to worse kidney health in people with HIV.
Methodology
A prospective cohort study measuring perirenal fat thickness and intrarenal artery resistive index in HIV-1-infected patients.
Potential Biases
Potential selection bias due to exclusion criteria.
Limitations
The study was limited to a single hospital and may not be generalizable to all HIV-1-infected populations.
Participant Demographics
102 HIV-1-infected patients, 78 men and 24 women, all Caucasian.
Statistical Information
P-Value
<0.01
Confidence Interval
1.01–1.14
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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