The Role of Adenomatous Polyposis Coli in Cerebral Cortex Development
Author Information
Author(s): Ivaniutsin Uladzislau, Chen Yijing, Mason John O, Price David J, Pratt Thomas
Primary Institution: The University of Edinburgh
Hypothesis
Apc is important for early events in the formation of the cerebral cortex.
Conclusion
Loss of Apc function disrupts multiple aspects of early cerebral cortical development, including cell number regulation, interkinetic nuclear migration, cell polarity, and cell type specification.
Supporting Evidence
- Loss of Apc leads to a decrease in the size of the proliferative pool.
- Disruption of interkinetic nuclear migration was observed in Apc mutant cerebral cortex.
- Cells in the Apc mutant exhibit altered expression of transcription factors associated with different brain regions.
Takeaway
Apc is like a guide that helps brain cells grow and organize properly; without it, the brain doesn't form correctly.
Methodology
The study used a Cre/LoxP strategy to inactivate Apc in developing cerebral cortical cells and assessed the effects on cell proliferation, migration, and identity.
Potential Biases
Potential bias in interpreting results due to the specific genetic model used.
Limitations
The study primarily focuses on early developmental stages and may not capture later effects of Apc loss.
Participant Demographics
Mice were used as the model organism, specifically focusing on embryonic development.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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