MDM2 SNP309 and Breast Cancer Risk in Taiwanese Women
Author Information
Author(s): Sun Ying-Fang, Leu Jyh-Der, Chen Su-Mei, Lin I-Feng, Lee Yi-Jang
Primary Institution: National Yang-Ming University
Hypothesis
The MDM2 SNP309 genotype is associated with the risk and age of onset of breast cancer in Taiwanese women.
Conclusion
The MDM2 SNP309 GG genotype may increase the risk of breast cancer and lead to an earlier age of diagnosis in Taiwanese women.
Supporting Evidence
- The GG genotype was associated with an odds ratio of 3.05 for breast cancer risk.
- The average age at diagnosis was significantly lower for GG genotype carriers compared to TT and TG carriers.
- The study adjusted for confounding factors such as age, BMI, and oral contraceptive use.
Takeaway
This study found that a specific gene change can make Taiwanese women more likely to get breast cancer and at a younger age.
Methodology
Genomic DNA was obtained from blood samples of 124 breast cancer patients and 97 healthy controls, and MDM2 SNP309 genotyping was performed using RFLP assay and analyzed with multivariate logistic regression.
Potential Biases
Potential bias due to differences in age and BMI between cases and controls.
Limitations
The study had a small sample size and did not assess other genetic factors that may influence breast cancer risk.
Participant Demographics
Participants were Taiwanese women aged 21 to 76 years, with a median age of 54 for breast cancer patients and 38 for controls.
Statistical Information
P-Value
0.0067
Confidence Interval
95% CI = 1.04 to 8.95
Statistical Significance
p = 0.0067
Digital Object Identifier (DOI)
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