An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus
2011
Understanding Brain-Derived Neurotrophic Factor and Its Role in the Hippocampus
publication
Evidence: moderate
Author Information
Author(s): Murray Patrick S., Holmes Philip V.
Primary Institution: The University of Georgia
Hypothesis
How does brain-derived neurotrophic factor (BDNF) influence hippocampal function and vulnerability to excitotoxicity?
Conclusion
Increased BDNF signaling enhances hippocampal function but also makes it more vulnerable to excitotoxic damage.
Supporting Evidence
- BDNF is crucial for neurogenesis and synaptic plasticity in the hippocampus.
- Exercise increases BDNF levels, enhancing learning and memory.
- Excessive BDNF signaling can lead to hyperexcitability and excitotoxic damage.
Takeaway
BDNF helps the brain grow and learn, but too much of it can make the brain more sensitive to damage.
Methodology
The paper reviews existing literature on BDNF's role in hippocampal development, neuroplasticity, and the effects of exercise.
Limitations
The review is based on existing literature and may not include all recent findings.
Digital Object Identifier (DOI)
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