Genetic Variability in Wegener's Granulomatosis
Author Information
Author(s): Stefan Wieczorek, Silvia Knaup, Wolfgang L. Gross, Jörg T. Epplen
Primary Institution: Ruhr University
Hypothesis
Genetic predisposition to Wegener's granulomatosis may arise from the interaction of certain genetic variations of RXRB and PPAR.
Conclusion
The study found no direct etiopathological role of RXRB and/or PPAR in Wegener's granulomatosis.
Supporting Evidence
- The study confirmed a strong association of the RXRB locus with Wegener's granulomatosis.
- None of the PPARA and PPARG SNPs showed association with Wegener's granulomatosis.
- No epistatic effect was seen between RXRB and PPARA/PPARG alleles.
Takeaway
Researchers looked at genes that might be linked to a disease called Wegener's granulomatosis but didn't find new important changes in those genes.
Methodology
The study involved genotyping SNPs in RXRB, PPARA, and PPARG in patients with Wegener's granulomatosis and healthy controls.
Limitations
The study could not identify novel variations in RXRB and did not find significant associations with PPARA and PPARG.
Participant Demographics
Patients were of German descent for at least two generations.
Statistical Information
P-Value
6.65 × 10−9
Confidence Interval
1.86–3.56
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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