Effect of Cryosurgery on Liver Blood Flow
Author Information
Author(s): N.J. Brown, P. Bayjoo, M.W.R. Reed
Primary Institution: The University of Sheffield
Hypothesis
Cryosurgery may result in a reduction in blood flow in normal or tumour-bearing liver by disruption of the microcirculation resulting in hypoxia.
Conclusion
Cryosurgery of normal liver and implanted tumour in rats produces a sharp reduction in microvascular blood flow that is maintained for at least 8 hours but reverses by 24 hours.
Supporting Evidence
- Cryosurgery significantly reduced red cell flux in both normal and tumour liver immediately after treatment.
- Red cell flux remained significantly reduced at 8 hours after treatment.
- By 24 hours, blood flow returned to preoperative levels.
- At 2 weeks, tumours were completely destroyed and replaced by a shallow scar.
Takeaway
Cryosurgery freezes and destroys tissue, which reduces blood flow in the liver for a short time, helping to kill cancer cells.
Methodology
The study involved 60 adult male rats divided into four groups, with measurements of red cell flux taken before and after cryosurgery using Laser Doppler Flowmetry.
Limitations
The study was conducted on rats, which may not fully represent human responses to cryosurgery.
Participant Demographics
60 adult male albino rats, weighing between 250-300g.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.01
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