Characterization of Mupirocin-Resistant Staphylococcus aureus in Nigeria and South Africa
Author Information
Author(s): Shittu Adebayo O, Udo Edet E, Lin Johnson
Primary Institution: Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria
Hypothesis
The study aims to characterize mupirocin-resistant Staphylococcus aureus isolates from Nigeria and South Africa.
Conclusion
Mupirocin-resistant Staphylococcus aureus isolates are emerging in Nigeria and South Africa, raising concerns for medical personnel.
Supporting Evidence
- All low-level mupirocin resistant isolates were MRSA and resistant to gentamicin, tetracycline, and trimethoprim.
- High-level mupirocin resistance was confirmed by PCR detection of the mupA gene.
- The genetic location of the resistance determinants was established by curing and transfer experiments.
Takeaway
Some bacteria that cause infections are becoming resistant to a medicine called mupirocin, which is used to treat skin infections. This is happening in Nigeria and South Africa.
Methodology
The study characterized 17 mupirocin-resistant S. aureus isolates using antibiogram, PCR-RFLP of the coagulase gene, and PFGE.
Participant Demographics
Isolates were obtained from clinical samples in Nigeria and South Africa.
Digital Object Identifier (DOI)
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