Ngb Polymorphisms and Ischemic Stroke in Southern Chinese Han Population
Author Information
Author(s): Lin Yi, Fang Ling, Xue Xie-Hua, Murong Shen-Xing, Wang Ning, Wu Zhi-Ying
Primary Institution: First Affiliated Hospital, Fujian Medical University
Hypothesis
Ngb may be one of the candidate genes associated with ischemic stroke.
Conclusion
Ngb polymorphism 89+104 t had protective effects on LVD and SVD in the Southern Chinese Han population.
Supporting Evidence
- The allele frequency of 89+104 t was decreased in stroke cases.
- The protective effect was more pronounced in female patients and those over 60 years old.
- Lower LDL-C levels and reduced hypertension were observed in 89+104 t allele carriers.
Takeaway
This study found that a specific gene variant might help protect against certain types of strokes in older women.
Methodology
A case-control study with 355 stroke cases and 158 controls, using PCR and sequencing to analyze Ngb polymorphisms.
Potential Biases
Potential confounding bias from differences in risk factors between hospitalized and community patients.
Limitations
Selection bias may have influenced results due to the hospital-based nature of the study.
Participant Demographics
513 participants, including 355 ischemic stroke cases and 158 controls, primarily from the Southern Chinese Han population.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI, 0.130 to 0.527
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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