IL-10 Gene Polymorphism and Retinal Artery Occlusion Risk
Author Information
Author(s): Weger Martin, Steinbrugger Iris, El-Shabrawi Yosuf, Wegscheider Beate Julia, Weger Wolfgang, Renner Wilfried, Schmut Otto, Haas Anton
Primary Institution: Medical University of Graz, Austria
Hypothesis
Is there an association between the IL10 -592C>A polymorphism and the presence of retinal artery occlusion (RAO)?
Conclusion
The IL10 [TCATA] haplotype may have a protective effect against retinal artery occlusion.
Supporting Evidence
- Carriers of the IL10 -592A-allele were found significantly more often in controls than among patients with RAO.
- The odds ratio for RAO associated with the IL10 -592A-allele was 0.65 after adjusting for confounding factors.
- Prevalences of arterial hypertension and current smoking were higher in RAO patients compared to controls.
Takeaway
People with a specific gene variant might be less likely to have a serious eye problem called retinal artery occlusion.
Methodology
A case-control study with 194 RAO patients and 257 controls, genotyping performed using TaqMan assay.
Limitations
IL-10 plasma concentrations were not measured.
Participant Demographics
Patients were primarily older adults, with a mean age of around 69 years.
Statistical Information
P-Value
0.008
Confidence Interval
95% CI: 0.44-0.97
Statistical Significance
p=0.008
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