DNMT3B Gene Variants and Colorectal Cancer Risk in Chinese
Author Information
Author(s): Fan Hong, Zhang Feng, Hu Jiabo, Liu Dongsheng, Zhao Zhujiang
Primary Institution: Southeast University
Hypothesis
The study investigates the association between DNMT3B gene polymorphisms and the risk of colorectal cancer in a Chinese population.
Conclusion
The DNMT3B -579G>T polymorphism may contribute to the genetic susceptibility to colorectal cancer, while the -149C>T variant does not appear to be a useful marker for predicting risk.
Supporting Evidence
- The allele frequency of -149C>T among patients was 0.73% and 0.65% among controls.
- Individuals with at least one -579G>T allele had a decreased risk of colorectal cancer.
- The study included 137 colorectal cancer patients and 308 controls matched for age and sex.
Takeaway
This study looked at how certain changes in a gene might affect the chances of getting colorectal cancer in Chinese people. It found that one change might lower the risk, while another doesn't help predict risk at all.
Methodology
The study used a case-control design with genotyping of DNMT3B polymorphisms in colorectal cancer patients and matched controls.
Potential Biases
Potential selection bias in choosing control subjects from a hospital setting.
Limitations
The study is limited to a specific ethnic group and may not be generalizable to other populations.
Participant Demographics
137 colorectal cancer patients and 308 healthy controls, matched for age and sex, all ethnically Chinese.
Statistical Information
P-Value
0.01 < p < 0.05
Confidence Interval
95% CI = 0.20–6.22 for 149C>T; 95% CI = 0.32–1.00 for 579G>T
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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