Efficacy of Azithromycin Therapy for Gingival Overgrowth from Cyclosporine A
Author Information
Author(s): Clementini Marco, Vittorini Gianluca, Crea Alessandro, Gualano Maria Rosaria, Macrì Ludovica Antonella, Deli Giorgio, La Torre Giuseppe
Primary Institution: Catholic University of the Sacred Heart-Rome, Italy
Hypothesis
How effective is AZM in terms of clinical outcomes in patients with GO induced by assumption of CsA?
Conclusion
A systemic antibiotic therapy without plaque and calculus removal is not able to reduce gingival overgrowth.
Supporting Evidence
- Only 5 RCTs met the inclusion criteria out of 24 articles retrieved.
- A 5-day course of Azithromycin with Scaling and Root Planing reduces gingival overgrowth.
- A 7-day course of metronidazole is effective only on concomitant bacterial over-infection.
- Future studies need to improve diagnostic methods and tools for better treatment outcomes.
Takeaway
This study looked at how well a medicine called Azithromycin works for people with gum problems caused by another medicine called Cyclosporine A. It found that Azithromycin helps when used with cleaning the teeth.
Methodology
A systematic review of Randomised Controlled Trials (RCTs) was conducted using databases like MEDLINE and EMBASE.
Limitations
The study faced great heterogeneity in treatment methods and outcomes, preventing a quantitative meta-analysis.
Participant Demographics
The included studies primarily involved renal transplant patients.
Digital Object Identifier (DOI)
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