Review of Clinical Trials for Malaria Prevention in Children
Author Information
Author(s): Moorthy Vasee S, Reed Zarifah, Smith Peter G
Hypothesis
How can the design and reporting of clinical trials for malaria prevention in children be improved?
Conclusion
The study emphasizes the need for standardization in clinical trial design and reporting to better evaluate malaria control measures.
Supporting Evidence
- 29 controlled trials of preventive malaria interventions were identified.
- Only one trial was designed to detect an effect on severe malaria.
- The need for standardization of clinical trial design has been affirmed as a priority area.
Takeaway
This study looks at how to make malaria prevention trials for kids better so we can understand which methods work best.
Methodology
The review identified and summarized methods used in 29 controlled trials of malaria preventive interventions in children published between 1990 and 2007.
Potential Biases
Variability in trial design and reporting may introduce bias in the evaluation of efficacy.
Limitations
The review does not provide specific details on the quality of the trials included.
Participant Demographics
Children in endemic countries.
Digital Object Identifier (DOI)
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