T Cell Polarization at the Virological Synapse
2010
Understanding T Cell Polarization in HIV-1 Spread
publication
Evidence: moderate
Author Information
Author(s): Clare Jolly
Primary Institution: University College London
Hypothesis
HIV-1 may exploit intercellular contacts to promote dissemination between permissive cells.
Conclusion
HIV-1 assembly and budding at the virological synapse is crucial for efficient viral dissemination.
Supporting Evidence
- HIV-1 can spread directly between T cells, enhancing its transmission efficiency.
- The virological synapse is a specialized structure that facilitates HIV-1 transfer.
- Polarization of viral proteins at the synapse is crucial for effective viral assembly.
Takeaway
HIV-1 spreads between T cells by forming special connections that help it move quickly from one cell to another.
Methodology
This review discusses the mechanisms of HIV-1 spread through virological synapses formed between infected and uninfected T cells.
Limitations
The review does not provide new experimental data but synthesizes existing knowledge.
Digital Object Identifier (DOI)
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