Knee Meniscal Extrusion and Cartilage Loss in Non-Osteoarthritic Individuals
Author Information
Author(s): Ding Changhai, Martel-Pelletier Johanne, Pelletier Jean-Pierre, Abram François, Raynauld Jean-Pierre, Cicuttini Flavia, Jones Graeme
Primary Institution: Menzies Research Institute, University of Tasmania
Hypothesis
What is the association between meniscal extrusion and knee cartilage loss in a largely non-osteoarthritic cohort?
Conclusion
Meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, primarily mediated by changes in subchondral bone.
Supporting Evidence
- Meniscal extrusion was found in 7% of individuals without OA.
- Obese individuals had nearly a fivefold increased risk for meniscal extrusion.
- Past knee injury was associated with a nearly fourfold increase in risk for meniscal extrusion.
Takeaway
If your knee has a part called the meniscus that is sticking out too much, it might mean you're losing some of the cushion in your knee over time.
Methodology
A longitudinal study over 2 years using MRI to assess meniscal extrusion and cartilage volume in 294 individuals.
Potential Biases
Potential underestimation of meniscal extrusion due to non-weight bearing MRI conditions.
Limitations
The study's low incidence rate of new meniscal extrusion limits the ability to confirm cross-sectional results in the longitudinal component.
Participant Demographics
Mean age 45 years, 58% female.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI = 1.02–1.25
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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