Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0)
2009
Regulation of Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0)
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Clinton Jones
Primary Institution: University of Nebraska, Lincoln
Hypothesis
How does bICP0 regulate innate immune responses during BoHV-1 infection?
Conclusion
bICP0 plays a crucial role in stimulating productive infection and inhibiting interferon-dependent transcription in the BoHV-1 infection cycle.
Supporting Evidence
- bICP0 inhibits interferon signaling by degrading IRF3.
- bICP0 is crucial for activating all viral promoters.
- A bICP0 deletion mutant does not induce plaques in permissive cells.
Takeaway
Bovine herpesvirus 1 has a protein called bICP0 that helps the virus grow and makes it harder for the cow's immune system to fight it off.
Methodology
The study involved transient transfection assays and analysis of viral gene expression in infected cells.
Limitations
The specific cellular proteins targeted for degradation by bICP0 have not been identified.
Digital Object Identifier (DOI)
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