SO2426 is a positive regulator of siderophore expression in Shewanella oneidensis MR-1
2011
SO2426 Regulates Siderophore Production in Shewanella oneidensis MR-1
publication
Evidence: moderate
Author Information
Author(s): Henne Kristene L, Wan Xiu-Feng, Wei Wei, Thompson Dorothea K
Primary Institution: Purdue University
Hypothesis
The study investigates the role of the SO2426 response regulator in the regulation of siderophore biosynthesis in Shewanella oneidensis MR-1.
Conclusion
SO2426 is a positive regulator of siderophore-mediated iron acquisition in Shewanella oneidensis MR-1.
Supporting Evidence
- SO2426 binds to a specific DNA motif that regulates siderophore biosynthesis genes.
- A deletion mutant of so2426 showed significantly reduced siderophore production.
- The study identified a consensus binding motif for SO2426 upstream of regulated genes.
Takeaway
SO2426 helps bacteria make a special substance to grab iron when they need it, especially when there's not enough iron around.
Methodology
The study used computational strategies to identify gene targets and biochemical assays to validate SO2426's role in siderophore biosynthesis.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website