Combination Chemotherapy for Influenza
Author Information
Author(s): Elena A. Govorkova, Robert G. Webster
Primary Institution: St. Jude Children’s Research Hospital
Hypothesis
Can combination chemotherapy improve treatment outcomes for influenza infections?
Conclusion
Combination chemotherapy shows promise in enhancing antiviral activity and reducing drug resistance in influenza treatment.
Supporting Evidence
- Combination therapy may reduce the emergence of drug-resistant influenza variants.
- Experimental data suggest that combining antiviral agents can enhance their effectiveness.
- Clinical trials are needed to confirm the benefits of combination therapy in humans.
Takeaway
Using more than one medicine together can help fight the flu better and stop the virus from becoming resistant to treatment.
Methodology
The review summarizes experimental and clinical data on the effectiveness of combination chemotherapy against influenza.
Potential Biases
Potential bias due to the limited number of antiviral drugs available for combination therapy.
Limitations
Limited clinical trials and the challenge of organizing them due to the high level of resistance to existing antiviral drugs.
Statistical Information
P-Value
0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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