Study on Docetaxel Plus S-1 Chemotherapy for Stage III Gastric Cancer
Author Information
Author(s): Terayama Masayoshi, Ohashi Manabu, Yamaguchi Kensei, Takahari Daisuke, Makuuchi Rie, Hayami Masaru, Ida Satoshi, Kumagai Koshi, Sano Takeshi, Nunobe Souya
Primary Institution: Japanese Foundation for Cancer Research, Tokyo, Japan
Hypothesis
This study aimed to assess the practical feasibility of docetaxel plus S-1 (DS) adjuvant chemotherapy and identify predictive factors for its completion in patients with pathological stage III gastric cancer.
Conclusion
Docetaxel plus S-1 adjuvant chemotherapy is feasible and safe for patients with stage III gastric cancer, with body composition factors like skeletal muscle index and intramuscular adipose content being useful predictors for treatment completion.
Supporting Evidence
- 67.8% of patients completed the DS chemotherapy regimen.
- Low skeletal muscle index and high intramuscular adipose content were significant predictors of treatment incompletion.
- Neutropenia was the most common adverse effect observed during treatment.
Takeaway
This study looked at how well patients could handle a specific cancer treatment and found that some body measurements could help doctors decide who might struggle with it.
Methodology
Data from patients who underwent radical gastrectomy and were diagnosed with stage III gastric cancer were retrospectively analyzed to assess completion rates and factors affecting treatment adherence.
Potential Biases
The study may have selection bias due to the exclusion of patients who did not meet eligibility criteria for the START-II trial.
Limitations
This was a single-institutional retrospective study with a small sample size, and the cutoff values for body composition may differ based on patient background.
Participant Demographics
The median age of participants was 61 years, with 50 men and 37 women.
Statistical Information
P-Value
0.005 for low SMI; 0.004 for high IMAC
Confidence Interval
95% confidence interval for relative dose intensity of docetaxel was 68.2–81.3%; for S-1 was 74.5–84.9%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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