Genetic Links Between IL-6R Variants and Lipid Profiles in Taiwanese Adolescents
Author Information
Author(s): Chu Nain-Feng, Lin Fu-Hung, Chin Hsien-Chuan, Hong Ye-Jen
Primary Institution: Taipei Medical University
Hypothesis
The study aims to analyze the genetic associations between IL-6R gene polymorphisms and lipid profiles in young adolescents in Taiwan.
Conclusion
The IL-6R gene variants are associated with dyslipidemia in girls but not in boys.
Supporting Evidence
- IL-6R variants were linked to higher triglycerides and lower HDL-C in girls.
- The AAT haplotype was associated with significant risks of dyslipidemia in girls.
- No significant associations were found between IL-6R variants and lipid profiles in boys.
Takeaway
This study found that certain genes can affect cholesterol and fat levels in girls, which might lead to heart problems.
Methodology
The study used a cross-sectional survey design, genotyping for IL-6R polymorphisms, and measuring lipid profiles in adolescents.
Potential Biases
Potential confounding factors related to lifestyle and dietary habits were not controlled.
Limitations
The study did not control for dietary intake and physical activity, which could affect lipid levels.
Participant Demographics
Participants included 418 boys and 441 girls with an average age of 13.1 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95%CI: 1.05-2.37
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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