Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP)
Author Information
Author(s): Deutskens Fabian, Lamp Benjamin, Riedel Christiane M, Wentz Eveline, Lochnit Günter, Doll Klaus, Thiel Heinz-Jürgen, Rümenapf Till
Primary Institution: Justus-Liebig-University Giessen, Germany
Hypothesis
Does vaccination with PregSure® BVD induce alloantibodies that lead to bovine neonatal pancytopenia?
Conclusion
The study found that vaccination with PregSure® BVD induces alloantibodies against MHC I, which are likely linked to the pathogenesis of BNP.
Supporting Evidence
- Over 4000 confirmed BNP cases were reported in Europe.
- The vaccine PregSure® BVD was retracted from the market due to its association with BNP.
- Antibodies from BNP-dams reacted with specific proteins on leukocytes of susceptible calves.
- MHC I was identified as a key antigen linked to the development of BNP.
Takeaway
Vaccinating cows with a certain vaccine can cause their calves to get sick because the vaccine makes the cows produce antibodies that attack the calves' blood cells.
Methodology
The study involved immunoprecipitation of surface proteins from bovine leukocytes and kidney cells using sera from dams with a confirmed case of BNP.
Potential Biases
Potential bias due to the selection of serum samples from specific groups of vaccinated and non-vaccinated animals.
Limitations
The study does not account for other potential factors influencing BNP occurrence beyond the vaccine.
Participant Demographics
The study involved bovine dams and their calves from various European countries.
Digital Object Identifier (DOI)
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