Role of Progesterone Receptor A and c-Met in Endometrial Attachment
Author Information
Author(s): Harduf Haggar, Goldman Shlomit, Shalev Eliezer
Primary Institution: Technion-Israel Institute of Technology
Hypothesis
The study investigates the expression and role of endometrial receptors, specifically Progesterone receptor A and c-Met, in endometrial receptivity and attachment processes.
Conclusion
The study suggests that Progesterone receptor A plays a significant role in endometrial receptivity and attachment, while c-Met's contribution is minor and related to its association with Plexin-B1.
Supporting Evidence
- Different protein expression patterns of endometrial receptors were observed between the tested endometrial cell lines.
- Attachment rates and growth of JAR spheroids into HEC-1A were significantly lower compared with RL95-2.
- Stimulation of PR with progesterone altered attachment rates to HEC-1A.
Takeaway
This study looks at how certain proteins help a baby attach to its mom's uterus, showing that one protein is really important while another one helps a little.
Methodology
The study used two endometrial cell lines and performed attachment and invasion assays with JAR spheroids, along with Western blot and RT-PCR analysis to study receptor expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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