2009 Update on HIV Drug Resistance Mutations
Author Information
Author(s): Diane E. Bennett, Ricardo J. Camacho, Dan Otelea, Daniel R. Kuritzkes, Hervé Fleury, Mark Kiuchi, Walid Heneine, Rami Kantor, Michael R. Jordan, Jonathan M. Schapiro, Anne-Mieke Vandamme, Paul Sandstrom, Charles A. Boucher, David van de Vijver, Soo-Yon Rhee, Tommy F. Liu, Deenan Pillay, Robert W. Shafer
Primary Institution: World Health Organization, Geneva, Switzerland
Hypothesis
The study aims to develop an updated list of surveillance drug resistance mutations (SDRMs) for transmitted HIV-1 drug resistance.
Conclusion
The updated SDRM list includes 93 mutations that are useful for ongoing and future studies of transmitted drug resistance.
Supporting Evidence
- The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations, 19 NNRTI-resistance mutations, and 40 PI-resistance mutations.
- More than 50% of the sequences analyzed were from non-subtype B viruses.
- The study followed the same procedures as the 2007 SDRM list to ensure consistency.
Takeaway
This study made a list of important mutations in HIV that can help doctors understand how the virus resists treatment, which is important for helping people stay healthy.
Methodology
The study identified mutations causing drug resistance by analyzing sequences from untreated individuals and comparing them against expert lists.
Potential Biases
There is a risk of including sequences from individuals with unreported prior treatment.
Limitations
The study may include low-level polymorphisms that could lead to falsely elevated estimates of transmitted resistance.
Participant Demographics
The analysis included sequences from 11,586 RT inhibitor-naïve individuals and 15,220 PI-naïve individuals.
Digital Object Identifier (DOI)
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