Bunyaviruses and the Type I Interferon System
2009
Bunyaviruses and the Type I Interferon System
publication
Evidence: moderate
Author Information
Author(s): Elliott Richard M., Weber Friedemann
Primary Institution: Centre for Biomolecular Sciences, School of Biology, University of St. Andrews, St. Andrews, Scotland, UK; Department of Virology, University of Freiburg, Germany
Hypothesis
How do bunyaviruses establish infection despite the presence of a powerful antiviral interferon system?
Conclusion
Bunyaviruses have evolved various mechanisms to evade the type I interferon response, which is crucial for their pathogenicity.
Supporting Evidence
- Bunyaviruses can evade the type I interferon response, which is crucial for their pathogenicity.
- Viruses like Rift Valley fever virus have been shown to block the induction of interferon.
- Different bunyaviruses utilize various strategies to suppress the host's immune response.
Takeaway
Bunyaviruses are tricky viruses that can hide from our body's defenses, making it hard for us to fight them off.
Limitations
The study highlights the need for more systematic characterization of virus-IFN interactions.
Digital Object Identifier (DOI)
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