Modeling the Metabolism of Geobacter metallireducens
Author Information
Author(s): Sun Jun, Sayyar Bahareh, Butler Jessica E, Pharkya Priti, Fahland Tom R, Famili Iman, Schilling Christophe H, Lovley Derek R, Mahadevan Radhakrishnan
Primary Institution: Genomatica Inc.
Hypothesis
How does the metabolism of Geobacter metallireducens differ from its close relative, Geobacter sulfurreducens?
Conclusion
The study developed a genome-scale metabolic model for G. metallireducens, revealing both similarities and differences in metabolism compared to G. sulfurreducens.
Supporting Evidence
- The model includes 747 genes and 697 reactions, highlighting unique metabolic capabilities.
- G. metallireducens can utilize a wider range of electron donors and acceptors than G. sulfurreducens.
- The study suggests that energy-inefficient reactions are up-regulated during growth with complex substrates.
Takeaway
Scientists created a computer model to understand how a bacteria called Geobacter metallireducens eats and grows, showing it can use different foods than a similar bacteria.
Methodology
The metabolic network was reconstructed using a modified procedure in SimPheny, incorporating gene annotations and biochemical information.
Limitations
The model may not capture all metabolic pathways due to missing genes and reactions.
Digital Object Identifier (DOI)
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