Plasma albumin determination on the Cobas Bio centrifugal analyser using bromocresol green
1983
Plasma Albumin Measurement Using Cobas Bio Analyser
Sample size: 30
publication
Evidence: moderate
Author Information
Author(s): J. R. Cowie, G. O. Evans
Primary Institution: Department of Toxicology, Wellcome Research Laboratories
Hypothesis
The study aims to develop an automated method for plasma albumin determination using bromocresol green on the Cobas Bio centrifugal analyser.
Conclusion
The automated BCG method shows good agreement with the immunoturbidimetric method for measuring plasma albumin.
Supporting Evidence
- The BCG assay was linear between 20 and 60 g/l.
- Good agreement was found between BCG and immunoturbidimetric methods over the range 22-57 g/l for 30 human samples.
- The precision of the BCG method was slightly better than the immunoturbidimetric procedure.
Takeaway
This study created a faster way to measure albumin in blood using a special dye and a machine, which works well for different types of samples.
Methodology
The study compared an automated BCG method with an immunoturbidimetric method for measuring albumin in plasma samples.
Limitations
The study does not specify limitations.
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