Genetic Factors Linked to Temporomandibular Disorder
Author Information
Author(s): Aneiros-Guerrero Angel, Lendinez Ana M, Palomares Arturo R, Perez-Nevot Beatriz, Aguado Lidia, Mayor-Olea Alvaro, Ruiz-Galdon Maximiliano, Reyes-Engel Armando
Primary Institution: University of Málaga, Spain
Hypothesis
Temporomandibular disorder (TMD) is a multifactorial syndrome related to genetic and epigenetic factors.
Conclusion
Certain genetic polymorphisms related to folate metabolism, oxidative stress, and neurotransmission are significantly associated with TMD syndrome.
Supporting Evidence
- Six genetic polymorphisms showed significant associations with TMD.
- Allele G of SHMT1 rs1979277 was associated with a higher risk of TMD.
- Null allele of GSTM1 was found more frequently in TMD patients.
- Polymorphism MTHFD1 rs2236225 was significantly associated with TMD.
- DRD4 long allele showed a trend towards association with TMD.
Takeaway
Some genes can make people more likely to have jaw pain and problems with their jaw joints.
Methodology
A case-control study with genotyping of 27 polymorphisms in 229 individuals, including 86 TMD patients and 143 healthy controls.
Potential Biases
Potential selection bias in participant recruitment.
Limitations
The study may not account for all environmental and psychological factors influencing TMD.
Participant Demographics
229 individuals (69% women), including 86 TMD patients and 143 healthy controls.
Statistical Information
P-Value
0.002, 0.013, 0.016, 0.037, 0.030
Confidence Interval
1.72, 9.25; 1.51, 5.21; 1.27, 7.50; 1.10, 5.00; 1.24, 4.36
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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