Delay-Induced Changes in Gene Expression in Gene Circuits
Author Information
Author(s): Maithreye R. Sarkar, Ram Rup Parnaik, Veena K. Sinha, Somdatta
Primary Institution: Centre for Cellular & Molecular Biology (CSIR), Hyderabad, India
Hypothesis
The repressor will take relatively longer time to be synthesized in the delay circuit compared to the basic circuit.
Conclusion
Delayed repression leads to a transient increase and heterogeneity in gene expression before stability is achieved.
Supporting Evidence
- Delayed repression induces transient increase in gene expression.
- Gene circuits with delay show greater heterogeneity in expression among cells.
- Both theoretical and experimental results support the overshoot phenomenon in gene expression.
Takeaway
When cells make proteins, sometimes they take a little longer to start, which can make them produce more at first and act differently from each other.
Methodology
The study involved constructing mathematical models and gene circuits to compare the effects of immediate versus delayed repression on gene expression.
Limitations
The theoretical models do not account for realistic details such as cell size variation during growth.
Digital Object Identifier (DOI)
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