Viral Hepatitis and HIV-Associated Tuberculosis in Thailand
Author Information
Author(s): Sirinak Chawin, Kittikraisak Wanitchaya, Pinjeesekikul Duangporn, Charusuntonsri Pricha, Luanloed Phinai, Srisuwanvilai La-ong, Nateniyom Sriprapa, Akksilp Somsak, Likanonsakul Sirirat, Sattayawuthipong Wanchai, Burapat Channawong, Varma Jay K
Primary Institution: Department of Health, Bangkok Metropolitan Administration, Bangkok, Thailand
Hypothesis
What are the risk factors for viral hepatitis and how do they affect TB treatment outcomes in HIV-infected patients?
Conclusion
Markers of viral hepatitis infection were common among HIV-infected TB patients in Thailand but were not strongly associated with death or clinical hepatitis during TB treatment.
Supporting Evidence
- 70 (9%) were reactive for HBsAg, 237 (31%) for anti-HCV.
- 493 (64%) were successfully treated at the end of TB treatment.
- Factors associated with HBsAg reactivity included being a man who has sex with men and having low TB knowledge.
- Injection drug use history was strongly associated with anti-HCV reactivity.
Takeaway
This study looked at people with both HIV and TB in Thailand to see how often they also had hepatitis. It found that many had hepatitis, but it didn't seem to make their TB treatment worse.
Methodology
An observational study evaluating risk factors for viral hepatitis and TB treatment outcomes among HIV-infected TB patients.
Potential Biases
Potential underreporting of injection drug use and other risk factors.
Limitations
Limited laboratory testing and potential non-representative sample of HIV-infected TB patients.
Participant Demographics
Median age of 34 years, predominantly male, with a significant portion having low TB knowledge.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI, 1.1–4.3 for HBsAg reactivity
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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