Probiotics Help Protect the Gut in Acute Pancreatitis in Rats
Author Information
Author(s): Lutgendorff Femke, Nijmeijer Rian M., Sandström Per A., Trulsson Lena M., Magnusson Karl-Eric, Timmerman Harro M., van Minnen L. Paul, Rijkers Ger T., Gooszen Hein G., Akkermans Louis M. A., Söderholm Johan D.
Primary Institution: Linköping University and University Medical Center Utrecht
Hypothesis
Can probiotics prevent intestinal barrier dysfunction and oxidative stress during acute pancreatitis?
Conclusion
Probiotic pre-treatment reduced intestinal barrier dysfunction and oxidative stress in rats with acute pancreatitis.
Supporting Evidence
- Probiotics reduced the increase in E. coli passage during acute pancreatitis.
- Probiotics normalized mucosal glutathione levels compared to placebo.
- Probiotic treatment decreased epithelial cell apoptosis by 70%.
- Probiotics prevented disruption of tight junction proteins in the intestine.
Takeaway
Giving probiotics to sick rats helped their intestines stay healthy and fight off damage during a serious illness called pancreatitis.
Methodology
Fifty-three male Sprague-Dawley rats were divided into five groups to study the effects of probiotics on intestinal barrier function during acute pancreatitis.
Potential Biases
Potential bias due to the use of a specific probiotic mixture and the controlled experimental conditions.
Limitations
The study was conducted in rats, and results may not directly translate to humans.
Participant Demographics
Male Sprague-Dawley rats, aged 50-70 days.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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